Four decades ago SIUT started its journey as an eight bed ward in Burns Unit of Civil Hospital Karachi. Gradually this small ward expanded its activities clinically and physically. In 1991 it was granted the status of an Institute by an Act of the Sindh Assembly.

In 2005 SIUT Trust was created as a charitable trust for the benefit of the public aiming to provide medical facilities and financial assistance to those who are at the end stage of renal ailments.

SIUT is located in the vicinity of Civil Hospital of Karachi with its hub of activities taking place at Dewan Farooq Medical Complex, named after a generous philanthropist whose donation helped built the complex.

In recent years SIUT has further expanded its facilities after receiving another generous donation from a philanthropist enabling the establishment of the Hanifa Sulaiman Dawood Oncology Centre. The building of the Oncology Centre is another milestone for SIUT, facilitating the treatment of various cancers including bladder cancer, kidney cancer, prostate cancer, adrenal cancer, testicular cancer and post transplant malignancies.